Possible Roles of Tumor-associated Carbohydrate Antigens1

Recent progress in the studies on the roles of carbohydrates has brought about critical discoveries, which allow us to have working hy potheses for understanding the roles of tumor-associated carbohydrate antigens. In this report, I focus my description on three different aspects of this progress. I discuss: (« ) the immunologie ¡il response to oligosaccharides aberrantly expressed under pathological conditions; (In possible roles of carbohydrate-dependent cell adhesion during tumor metastasis; and (c) the roles of carbohydrates in modulating the functions of proteins that attach those carbohydrates. These three areas in the roles of carbo hydrates will likely be the target for continuous research efforts to reveal the roles of tumor-associated carbohydrates.